Enigma of Sepia tier list: ranking of the best characters in April 2025

In Enigma of Sepia, all the heroes are inspired by famous anime characters,the best-known shonen of the last 10 years. But not all characters are created equal: some are indispensable, others are not very effective. In this Enigma of Sepia tier list, I invite you to discover the best characters and those you'll need to replace quickly!

Enigma of Sepia tier list: the character ranking system

With dozens of characters inspired by the most famous shonens, it's hard to choose your heroines in Enigma of Sepia! To help you target the best characters for your draws, and avoid the worst ones, we've divided them into tiers. Tier S+ is for the most effective characters, and Tier D is for the worst characters in this Enigma of Sepia tier list.

• Tier S+: Sanguina, Chronis, Satoria, Sepia.
• Tier S: Vespera, Yukari, Erenor, Nova, Little Rasi, Lena Frost, Eclipsea, Lumina, Carmilla.
• Tier A: Aqua Sera, Celestia, Giselle, Morgana, Sandra, Elysia, Sylphyra, Naldra.
• Tier B: Nora Zorana, Crimson, Denise, Ivy Lynn, Caelestis, Bipolaris, Mentora, Scientia.
• Tier C: Ginara, Eldwyn, Sylvia, Dr. Lorena, Ayame, Eliza Thorn, Aurora, Alfyria.
• Tier D: Little Sai, Lyra, Royelle, Levia, Yurina, Cheshire, Mirage.

Enigma of Sepia tier list: the complete ranking of heroes

To end the suspense, here's the Enigma of Sepia tier list of the game's characters. Here are the heroes, ranked from best to least effective:

Sanguina, the best DPS in Enigma of Sepia

As you may have noticed, Sanguina is inspired by Sukuna from Jujutsu Kaisen. With her SP rarity, she inflicts the most damage in our Enigma of Sepia tier list.

She's also indispensable for crowd control, so she's an absolutely essential mid and late game character.

Chronis, the best drinker in the Enigma of Sepia tier list

Chronis was inspired by the character Jotaro in Jojo's Bizarre Adventure. She also has an SP rarity, but unlike Sanguina, she buffs the units in her team and is able to apply a curse to enemies.

She absolutely must find her place in your team!

Satoria, the best AoE in Enigma of Sepia

Another character from Jujutsu Kaisen! Satoria is inspired by Gojo and has a rare SP, like the other two heroines in our Enigma of Sepia tier list.

Satoria applies AoE, which comes in handy to complement Sanguina, who is a monocible character. And like Chronis, she can also apply curses.

Our Enigma of Sepia tier list ends here. I hope it helps you put together the best possible team in this shonen-inspired gacha RPG.